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1

The next generation of CRISPR–Cas technologies and applications

Pickar-Oliver, Adrian, Gersbach, Charles A.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2019

Language:

english

File:

PDF, 1.77 MB

english, 2019

2

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Gaj, Thomas, Gersbach, Charles A., Barbas, Carlos F.

Journal:

Trends in Biotechnology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

3

Genome Editing Technologies for Gene and Cell Therapy

Maeder, Morgan L., Gersbach, Charles A.

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 2.46 MB

english, 2016

4

Advances in targeted genome editing

Perez-Pinera, Pablo, Ousterout, David G, Gersbach, Charles A

Journal:

Current Opinion in Chemical Biology

Year:

2012

Language:

english

File:

PDF, 953 KB

english, 2012

5

Aggregate Investment Externalities and Macroprudential Regulation

GERSBACH, HANS, ROCHET, JEAN-CHARLES

Journal:

Journal of Money, Credit and Banking

Year:

2012

Language:

english

File:

PDF, 924 KB

english, 2012

6

Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine

Gersbach, Charles A, Perez-Pinera, Pablo

Journal:

Expert Opinion on Therapeutic Targets

Year:

2014

Language:

english

File:

PDF, 264 KB

english, 2014

7

Targeted genome and epigenome editing using engineered TALE and CRISPR/Cas9 technologies

Gersbach, Charles A

Journal:

Year:

2014

Language:

english

File:

PDF, 194 KB

english, 2014

8

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy

Ousterout, David G., Kabadi, Ami M., Thakore, Pratiksha I., Majoros, William H., Reddy, Timothy E., Gersbach, Charles A.

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

9

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Hilton, Isaac B, D'Ippolito, Anthony M, Vockley, Christopher M, Thakore, Pratiksha I, Crawford, Gregory E, Reddy, Timothy E, Gersbach, Charles A

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

10

Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

Josephs, Eric A., Kocak, D. Dewran, Fitzgibbon, Christopher J., McMenemy, Joshua, Gersbach, Charles A., Marszalek, Piotr E.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 6.78 MB

english, 2015

11

691. A Light-Inducible CRISPR/Cas9 System for Control of Endogenous Gene Activation

Toth, Lauren P., Gersbach, Charles A.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 591 KB

english, 2015

12

Expanding the CRISPR Toolbox: Targeting RNA with Cas13b

Barrangou, Rodolphe, Gersbach, Charles A.

Journal:

Year:

2017

Language:

english

File:

PDF, 593 KB

english, 2017

13

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Klann, Tyler S, Black, Joshua B, Chellappan, Malathi, Safi, Alexias, Song, Lingyun, Hilton, Isaac B, Crawford, Gregory E, Reddy, Timothy E, Gersbach, Charles A

Journal:

Nature Biotechnology

Year:

2017

Language:

english

File:

PDF, 3.10 MB

english, 2017

14

Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2

Pathak, Gopal P., Spiltoir, Jessica I., Höglund, Camilla, Polstein, Lauren R., Heine-Koskinen, Sari, Gersbach, Charles A., Rossi, Jari, Tucker, Chandra L.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 4.07 MB

english, 2017

15

Capital Regulation and Credit Fluctuations

Gersbach, Hans, Rochet, Jean-Charles

Journal:

Journal of Monetary Economics

Year:

2017

Language:

english

File:

PDF, 701 KB

english, 2017

16

Gene therapies for hemophilia hit the mark in clinical trials

Pickar, Adrian K, Gersbach, Charles A

Journal:

Nature Medicine

Year:

2018

Language:

english

File:

PDF, 188 KB

english, 2018

17

Aggregate Investment Externalities and Macroprudential Regulation

Gersbach, Hans, Rochet, Jean-Charles

Journal:

SSRN Electronic Journal

Year:

2012

Language:

english

File:

PDF, 634 KB

english, 2012

18

Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro

Charles A. Gersbach, Benjamin A. Byers, Grace K. Pavlath, Robert E. Guldberg, Andrés J. García

Journal:

Biotechnology and Bioengineering

Year:

2004

Language:

english

File:

PDF, 1.88 MB

english, 2004

19

In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts

Charles A. Gersbach, Robert E. Guldberg, Andrés J. García

Journal:

Journal of Cellular Biochemistry

Year:

2007

Language:

english

File:

PDF, 580 KB

english, 2007

20

Identification of novel Runx2 targets in osteoblasts: Cell type-specific BMP-dependent regulation of Tram2

Steven Pregizer, Artem Barski, Charles A. Gersbach, Andrés J. García, Baruch Frenkel

Journal:

Journal of Cellular Biochemistry

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

21

Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries

Michael A. Lan, Charles A. Gersbach, Kristin E. Michael, Benjamin G. Keselowsky, Andrés J. García

Journal:

Year:

2005

Language:

english

File:

PDF, 352 KB

english, 2005

22

Virus-based gene therapy strategies for bone regeneration

Jennifer E. Phillips, Charles A. Gersbach, Andrés J. García

Journal:

Year:

2007

Language:

english

File:

PDF, 285 KB

english, 2007

23

Biomaterial-mediated retroviral gene transfer using self-assembled monolayers

Charles A. Gersbach, Sean R. Coyer, Joseph M. Le Doux, Andrés J. García

Journal:

Year:

2007

Language:

english

File:

PDF, 386 KB

english, 2007

24

Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype

Charles A. Gersbach, Benjamin A. Byers, Grace K. Pavlath, Andrés J. García

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 796 KB

english, 2004

25

Handbook of Stem Cells || Engineered Proteins for Controlling Gene Expression

Gersbach, Charles A.

Year:

2013

Language:

english

File:

PDF, 612 KB

english, 2013

26

Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients

Ousterout, David G, Perez-Pinera, Pablo, Thakore, Pratiksha I, Kabadi, Ami M, Brown, Matthew T, Qin, Xiaoxia, Fedrigo, Olivier, Mouly, Vincent, Tremblay, Jacques P, Gersbach, Charles A

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 1.42 MB

english, 2013

27

Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors

Polstein, Lauren R., Gersbach, Charles A.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

28

Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage

Brunger, Jonathan M., Huynh, Nguyen P. T., Guenther, Caitlin M., Perez-Pinera, Pablo, Moutos, Franklin T., Sanchez-Adams, Johannah, Gersbach, Charles A., Guilak, Farshid

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.62 MB

english, 2014

29

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

Glass, Katherine A., Link, Jarrett M., Brunger, Jonathan M., Moutos, Franklin T., Gersbach, Charles A., Guilak, Farshid

Journal:

Year:

2014

Language:

english

File:

PDF, 2.61 MB

english, 2014

30

Synthetic Zinc Finger Proteins: The Advent of Targeted Gene Regulation and Genome Modification Technologies

Gersbach, Charles A., Gaj, Thomas, Barbas, Carlos F.

Journal:

Accounts of Chemical Research

Year:

2014

Language:

english

File:

PDF, 4.12 MB

english, 2014

31

Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression

Kabadi, Ami M., Gersbach, Charles A.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.60 MB

english, 2014

32

Special Issue on Engineered DNA-Binding Proteins

Kabadi, Ami M., Gersbach, Charles A.

Journal:

ACS Synthetic Biology

Year:

2014

Language:

english

File:

PDF, 123 KB

english, 2014

33

Genome engineering: the next genomic revolution

Gersbach, Charles A

Journal:

Year:

2014

Language:

english

File:

PDF, 617 KB

english, 2014

34

Comparing Genome Editing Technologies

Gersbach, Charles A., Gaj, Thomas, Barbas, Carlos F.

Journal:

Genetic Engineering & Biotechnology News

Year:

2014

Language:

english

File:

PDF, 476 KB

english, 2014

35

Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells

Diekman, Brian O., Thakore, Pratiksha I., O'Connor, Shannon K., Willard, Vincent P., Brunger, Jonathan M., Christoforou, Nicolas, Leong, Kam W., Gersbach, Charles A., Guilak, Farshid

Journal:

Tissue Engineering Part A

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

36

The role of single-cell analyses in understanding cell lineage commitment

Gibson, Tyler M., Gersbach, Charles A.

Journal:

Biotechnology Journal

Year:

2013

Language:

english

File:

PDF, 699 KB

english, 2013

37

A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

Chakraborty, Syandan, Ji, HaYeun, Kabadi, Ami M., Gersbach, Charles A., Christoforou, Nicolas, Leong, Kam W.

Journal:

Stem Cell Reports

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

38

Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis

Chakraborty, Syandan, Ji, HaYeun, Chen, Jack, Gersbach, Charles A., Leong, Kam W.

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

39

814. Biomaterial-Mediated Retroviral Gene Delivery

Gersbach, Charles A., Coyer, Sean R., Le Doux, Joseph M., Garcia, Andres J.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

40

577. Inducible Regulation of Runx2-Stimulated Osteogenesis

Gersbach, Charles A., Le Doux, Joseph M., Guldberg, Robert E., Garcia, Andres J.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

41

Genetic Engineering for Skeletal Regenerative Medicine

Gersbach, Charles A., Phillips, Jennifer E., García, Andrés J.

Journal:

Annual Review of Biomedical Engineering

Year:

2007

Language:

english

File:

PDF, 412 KB

english, 2007

42

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

Polstein, Lauren R, Gersbach, Charles A

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 732 KB

english, 2015

43

Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain

Kabadi, Ami M., Thakore, Pratiksha I., Vockley, Christopher M., Ousterout, David G., Gibson, Tyler M., Guilak, Farshid, Reddy, Timothy E., Gersbach, Charles A.

Journal:

ACS Synthetic Biology

Year:

2015

Language:

english

File:

PDF, 5.97 MB

english, 2015

44

Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum

Frank, Christopher L, Liu, Fang, Wijayatunge, Ranjula, Song, Lingyun, Biegler, Matthew T, Yang, Marty G, Vockley, Christopher M, Safi, Alexias, Gersbach, Charles A, Crawford, Gregory E, West, Anne E

Journal:

Nature Neuroscience

Year:

2015

Language:

english

File:

PDF, 3.06 MB

english, 2015

45

Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment

Gibson, Tyler M., Gersbach, Charles A.

Journal:

Integrative Biology

Year:

2015

Language:

english

File:

PDF, 3.10 MB

english, 2015

46

Correction of Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients Through Genomic Excision of Exon 51 by Zinc Finger Nucleases

Ousterout, David G, Kabadi, Ami M, Thakore, Pratiksha I, Perez-Pinera, Pablo, Brown, Matthew T, Majoros, William H, Reddy, Timothy E, Gersbach, Charles A

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

47

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Polstein, Lauren R., Perez-Pinera, Pablo, Kocak, D. Dewran, Vockley, Christopher M., Bledsoe, Peggy, Song, Lingyun, Safi, Alexias, Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.

Journal:

Genome Research

Year:

2015

Language:

english

File:

PDF, 4.99 MB

english, 2015

48

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Thakore, Pratiksha I, D'Ippolito, Anthony M, Song, Lingyun, Safi, Alexias, Shivakumar, Nishkala K, Kabadi, Ami M, Reddy, Timothy E, Crawford, Gregory E, Gersbach, Charles A

Journal:

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

49

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Thakore, Pratiksha I, Black, Joshua B, Hilton, Isaac B, Gersbach, Charles A

Journal:

Year:

2016

Language:

english

File:

PDF, 6.67 MB

english, 2016

50

In Vivo Zinc Finger Nuclease-Mediated Targeted Integration of a Glucose-6-Phosphatase Transgene Promotes Survival in Mice with Glycogen Storage Disease Type IA

Landau, Dustin J., Brooks, Elizabeth Drake, Perez-Pinera, Pablo, Amarasekara, Hiruni, Mefferd, Adam, Li, Songtao, Bird, Andrew, Gersbach, Charles A., Koeberl, Dwight D.

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 7.73 MB

english, 2016